One Take Session. To record a video or audio clip in one continuous take without any cuts.

Gabe Bondoc does many OTSs on youtube.
Gina: "I want people to know that I can actually sing well without studio effects and autotune."

Zack: "Then let's do an OTS of a song you want to sing and put it on our youtube channel."
dari youmakemyslackstighter Sabtu, 10 Juli 2010
Plain & simple - OTS is Off that Shit ! Or "on one".
Wow, look at him go ! He's OTS for sure !
dari Jayare a.k.a. goo1z Minggu, 27 Mei 2007
On The Side

Meaning having a person on the side other than your significant other.
"Wow Mike is taking a very long lunch today with his OTS."
dari infestacool Kamis, 05 Februari 2009
Off the shits.

High as fuck
Drunk
Trippy
Fucked up
Boy we smoked 8 loud blunts, you know I was OTS .

MY nigga you off the shits

You off the shits breh

I'm tryna get ots . you wanna match ?
dari Kiddoe Kwasiee Kamis, 20 Februari 2014
ON THE SACK!
THAT BITCH IS OTS!
dari GORILLA PIMPIN Senin, 07 Juni 2010
Off The Spectrum. Kinda like Off The Hook, or Off the Snuggies, but better because it's Spectrum. Usually refers to the visible light region of the electromagnetic spectrum.
This party is OTS!
dari wizrdry Rabu, 10 Juni 2009
"Oh the Shame" like if you shit your pants or you dropped the dutchie
Guy1: Oh shit man, I dropped the last water bong Bob Marley ever used!!
Guy2: You dick! Everyone will hate you forever
Guy1: OTS TT~TT
dari Incredible Chemical Rabu, 11 Agustus 2010

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